A workspace for Simon's two-stage Phase II trial design

BioStatHub is a workspace for Simon's two-stage Phase II trial design. Generate valid candidate designs, transparently compare their trade-offs, select the design that fits your study, and document the result in a reproducible report.

Generate valid candidate designs

Enter the null response rate, target response rate, Type I error, and desired power to compute statistically valid Optimal, Minimax, and Admissible Simon two-stage designs with exact binomial probabilities.

Compare the trade-offs

Review maximum sample size, expected sample size under the null hypothesis, probability of early termination, decision boundaries, and robustness side by side before making your own informed decision.

Decide on the design that fits your study

You make the call, not a black-box recommendation. Select the design that best fits your study and record the rationale, so reviewers can trace how the final design was chosen.

Document the final design

Produce a reproducible record of your selected design and its rationale with a free online Final Protocol with frozen parameters and validation evidence, a read-only snapshot to share with your team, and PDF/Word report export as the full record.